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Single cell biology - a Keystone Symposia report

Item Type:Article
Title:Single cell biology - a Keystone Symposia report
Creators Name:Cable, J. and Elowitz, M.B. and Domingos, A.I. and Habib, N. and Itzkovitz, S. and Hamidzada, H. and Balzer, M.S. and Yanai, I. and Liberali, P. and Whited, J. and Streets, A. and Cai, L. and Stergachis, A.B. and Hong, C.K.Y. and Keren, L. and Guilliams, M. and Alon, U. and Shalek, A.K. and Hamel, R. and Pfau, S.J. and Raj, A. and Quake, S.R. and Zhang, N.R. and Fan, J. and Trapnell, C. and Wang, B. and Greenwald, N.F. and Vento-Tormo, R. and Santos, S.D.M. and Spencer, S.L. and Garcia, H.G. and Arekatla, G. and Gaiti, F. and Arbel-Goren, R. and Rulands, S. and Junker, J.P. and Klein, A.M. and Morris, S.A. and Murray, J.I. and Galloway, K.E. and Ratz, M. and Romeike, M.
Abstract:Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state-transcriptional, epigenetic, and other characteristics - can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17-19, 2021, experts in single cell biology met virtually for the Keystone eSymposium "Single Cell Biology" to discuss advances both in single cell applications and technologies.
Keywords:Development, Differentiation, Lineage Tracing, Reprogramming, Single Cell Sequencing, Spatial Transcriptomics, Animals
Source:Annals of the New York Academy of Sciences
Page Range:74-97
Date:December 2021
Official Publication:https://doi.org/10.1111/nyas.14692
PubMed:View item in PubMed

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