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Retinal optical coherence tomography in neuromyelitis optica

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Item Type:Article
Title:Retinal optical coherence tomography in neuromyelitis optica
Creators Name:Oertel, F.C. and Specovius, S. and Zimmermann, H.G. and Chien, C. and Motamedi, S. and Bereuter, C. and Cook, L. and Lana Peixoto, M.A. and Fontanelle, M.A. and Kim, H.J. and Hyun, J.W. and Palace, J. and Roca-Fernandez, A. and Leite, M.I. and Sharma, S. and Ashtari, F. and Kafieh, R. and Dehghani, A. and Pourazizi, M. and Pandit, L. and D'Cunha, A. and Aktas, O. and Ringelstein, M. and Albrecht, P. and May, E. and Tongco, C. and Leocani, L. and Pisa, M. and Radaelli, M. and Martinez-Lapiscina, E.H. and Stiebel-Kalish, H. and Siritho, S. and de Seze, J. and Senger, T. and Havla, J. and Marignier, R. and Cobo-Calvo, A. and Bichuetti, D. and Tavares, I.M. and Asgari, N. and Soelberg, K. and Altintas, A. and Yildirim, R. and Tanriverdi, U. and Jacob, A. and Huda, S. and Rimler, Z. and Reid, A. and Mao-Draayer, Y. and Soto de Castillo, I. and Petzold, A. and Green, A.J. and Yeaman, M.R. and Smith, T. and Brandt, A.U. and Paul, F.
Abstract:BACKGROUND AND OBJECTIVES: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts. METHODS: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary outcomes were thickness of peripapillary retinal nerve fiber layer (pRNFL) and visual acuity (VA). RESULTS: Eyes with ON (NMOSD-ON, N = 260) or without ON (NMOSD-NON, N = 241) were assessed compared with HCs (N = 136). In NMOSD-ON, GCIP layer (57.4 ± 12.2 μm) was reduced compared with HC (GCIP layer: 81.4 ± 5.7 μm, p < 0.001). GCIP layer loss (-22.7 μm) after the first ON was higher than after the next (-3.5 μm) and subsequent episodes. pRNFL observations were similar. NMOSD-NON exhibited reduced GCIP layer but not pRNFL compared with HC. VA was greatly reduced in NMOSD-ON compared with HC eyes, but did not differ between NMOSD-NON and HC. DISCUSSION: Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation.
Keywords:All Imaging, Devic's Syndrome, Retina, Visual loss
Source:Neurology Neuroimmunology & Neuroinflammation
Publisher:American Academy of Neurology
Page Range:e1068
Date:November 2021
Additional Information:Erratum in: Neurol Neuroimmunol Neuroinflamm 8(6):e1068.
Official Publication:https://doi.org/10.1212/NXI.0000000000001068
PubMed:View item in PubMed

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