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RNA dynamics in Alzheimer’s disease

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Item Type:Review
Title:RNA dynamics in Alzheimer’s disease
Creators Name:Rybak-Wolf, A. and Plass, M.
Abstract:Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder that heavily burdens healthcare systems worldwide. There is a significant requirement to understand the still unknown molecular mechanisms underlying AD. Current evidence shows that two of the major features of AD are transcriptome dysregulation and altered function of RNA binding proteins (RBPs), both of which lead to changes in the expression of different RNA species, including microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and messenger RNAs (mRNAs). In this review, we will conduct a comprehensive overview of how RNA dynamics are altered in AD and how this leads to the differential expression of both short and long RNA species. We will describe how RBP expression and function are altered in AD and how this impacts the expression of different RNA species. Furthermore, we will also show how changes in the abundance of specific RNA species are linked to the pathology of AD.
Keywords:Alzheimer’s Disease, Neurodegenerative Diseases, RNA Binding Proteins, RNA Processing, Post-Transcriptional Regulation, Alternative Splicing, miRNAs, circRNAs, lncRNAs, Animals
Source:Molecules
ISSN:1420-3049
Publisher:MDPI
Volume:26
Number:17
Page Range:5113
Date:1 September 2021
Official Publication:https://doi.org/10.3390/molecules26175113
PubMed:View item in PubMed

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