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| Item Type: | Article |
|---|---|
| Title: | African naked mole-rats demonstrate extreme tolerance to hypoxia and hypercapnia |
| Creators Name: | Park, T.J. and Smith, E.S.J. and Reznick, J. and Bennett, N.C. and Applegate, Daniel T and Larson, J. and Lewin, G.R. |
| Abstract: | Naked mole-rats are extremely tolerant to low concentrations of oxygen (hypoxia) and high concentrations of carbon dioxide (hypercapnia), which is consistent with the environment that they inhabit. Naked mole-rats combine subterranean living with living in very densely populated colonies where oxygen becomes depleted and carbon dioxide accumulates. In the laboratory, naked mole-rats fully recover from 5 h exposure to 5% O(2) and 5 h exposure to 80% CO(2), whereas both conditions are rapidly lethal to similarly sized laboratory mice. During anoxia (0% O(2)) naked mole-rats enter a suspended animation-like state and switch from aerobic metabolism of glucose to anaerobic metabolism of fructose. Additional fascinating characteristics include that naked mole-rats show intrinsic brain tolerance to anoxia; a complete lack of hypoxia-induced and CO(2)-induced pulmonary edema; and reduced aversion to high concentrations of CO(2) and acidic fumes. Here we outline a constellation of physiological and molecular adaptations that correlate with the naked mole-rat’s hypoxic/hypercapnic tolerance and which offer potential targets for ameliorating pathological conditions in humans, such as the damage caused during cerebral ischemia. |
| Keywords: | Physiological Adaptation, Hypercapnia, Hypoxia, Oxygen, Animals, Mice, Mole Rats |
| Source: | Advances in Experimental Medicine and Biology |
| Series Name: | Advances in Experimental Medicine and Biology |
| Title of Book: | The Extraordinary Biology of the Naked Mole-Rat |
| ISSN: | 0065-2598 |
| ISBN: | 978-3-030-65943-1 |
| Publisher: | Springer |
| Volume: | 1319 |
| Number: | 1319 |
| Page Range: | 255-269 |
| Number of Pages: | 445 |
| Date: | 24 August 2021 |
| Official Publication: | https://doi.org/10.1007/978-3-030-65943-1_9 |
| PubMed: | View item in PubMed |
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