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| Item Type: | Article |
|---|---|
| Title: | Cold-aggravated pain in humans caused by a hyperactive Na(V)1.9 channel mutant |
| Creators Name: | Leipold, E. and Hanson-Kahn, A. and Frick, M. and Gong, P. and Bernstein, J.A. and Voigt, M. and Katona, I. and Oliver Goral, R. and Altmüller, J. and Nürnberg, P. and Weis, J. and Hübner, C.A. and Heinemann, S.H. and Kurth, I. |
| Abstract: | Gain-of-function mutations in the human SCN11A-encoded voltage-gated Na(+) channel Na(V)1.9 cause severe pain disorders ranging from neuropathic pain to congenital pain insensitivity. However, the entire spectrum of the Na(V)1.9 diseases has yet to be defined. Applying whole-exome sequencing we here identify a missense change (p.V1184A) in NaV1.9, which leads to cold-aggravated peripheral pain in humans. Electrophysiological analysis reveals that p.V1184A shifts the voltage dependence of channel opening to hyperpolarized potentials thereby conferring gain-of-function characteristics to Na(V)1.9. Mutated channels diminish the resting membrane potential of mouse primary sensory neurons and cause cold-resistant hyperexcitability of nociceptors, suggesting a mechanistic basis for the temperature dependence of the pain phenotype. On the basis of direct comparison of the mutations linked to either cold-aggravated pain or pain insensitivity, we propose a model in which the physiological consequence of a mutation, that is, augmented versus absent pain, is critically dependent on the type of Na(V)1.9 hyperactivity. |
| Keywords: | Cold Temperature, Inbred C57BL Mice, Missense Mutation, NAV1.9 Voltage-Gated Sodium Channel, Pain, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 6 |
| Page Range: | 10049 |
| Date: | 8 December 2015 |
| Official Publication: | https://doi.org/10.1038/ncomms10049 |
| PubMed: | View item in PubMed |
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