![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
842kB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary Material)
3MB |
| Item Type: | Article |
|---|---|
| Title: | Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia |
| Creators Name: | Herling, C.D. and Abedpour, N. and Weiss, J. and Schmitt, A. and Jachimowicz, R.D. and Merkel, O. and Cartolano, M. and Oberbeck, S. and Mayer, P. and Berg, V. and Thomalla, D. and Kutsch, N. and Stiefelhagen, M. and Cramer, P. and Wendtner, C.M. and Persigehl, T. and Saleh, A. and Altmüller, J. and Nürnberg, P. and Pallasch, C. and Achter, V. and Lang, U. and Eichhorst, B. and Castiglione, R. and Schäfer, S.C. and Büttner, R. and Kreuzer, K.A. and Reinhardt, H.C. and Hallek, M. and Frenzel, L.P. and Peifer, M. |
| Abstract: | Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL) patients that developed resistance upon BCL2-inhibition by venetoclax. Here, we report recurrent mutations in BTG1 (2 patients) and homozygous deletions affecting CDKN2A/B (3 patients) that developed during treatment, as well as a mutation in BRAF and a high-level focal amplification of CD274 (PD-L1) that might pinpoint molecular aberrations offering structures for further therapeutic interventions. |
| Keywords: | Heterocyclic Bridged Bicyclo Compounds, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p18, Neoplasm Drug Resistance, B-Cell Chronic Lymphocytic Leukemia, Mutation, Neoplasm Proteins, Sulfonamides / Therapeutic Use |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 9 |
| Number: | 1 |
| Page Range: | 727 |
| Date: | 20 February 2018 |
| Official Publication: | https://doi.org/10.1038/s41467-018-03170-7 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
