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| Item Type: | Article |
|---|---|
| Title: | Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids |
| Creators Name: | Alcala, N. and Leblay, N. and Gabriel, A.A.G. and Mangiante, L. and Hervas, D. and Giffon, T. and Sertier, A.S. and Ferrari, A. and Derks, J. and Ghantous, A. and Delhomme, T.M. and Chabrier, A. and Cuenin, C. and Abedi-Ardekani, B. and Boland, A. and Olaso, R. and Meyer, V. and Altmuller, J. and Le Calvez-Kelm, F. and Durand, G. and Voegele, C. and Boyault, S. and Moonen, L. and Lemaitre, N. and Lorimier, P. and Toffart, A.C. and Soltermann, A. and Clement, J.H. and Saenger, J. and Field, J.K. and Brevet, M. and Blanc-Fournier, C. and Galateau-Salle, F. and Le Stang, N. and Russell, P.A. and Wright, G. and Sozzi, G. and Pastorino, U. and Lacomme, S. and Vignaud, J.M. and Hofman, V. and Hofman, P. and Brustugun, O.T. and Lund-Iversen, M. and Thomas de Montpreville, V. and Muscarella, L.A. and Graziano, P. and Popper, H. and Stojsic, J. and Deleuze, J.F. and Herceg, Z. and Viari, A. and Nuernberg, P. and Pelosi, G. and Dingemans, A.M.C. and Milione, M. and Roz, L. and Brcic, L. and Volante, M. and Papotti, M.G. and Caux, C. and Sandoval, J. and Hernandez-Vargas, H. and Brambilla, E. and Speel, E.J.M. and Girard, N. and Lantuejoul, S. and McKay, J.D. and Foll, M. and Fernandez-Cuesta, L. |
| Abstract: | The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms. |
| Keywords: | Carcinoid Tumor, Comparative Genomic Hybridization, Datasets as Topic, Genomics, Homeodomain Proteins, Intracellular Signaling Peptides and Proteins, Large Cell Carcinoma, Lung, Lung Neoplasms, Machine Learning, Membrane Proteins, Nerve Tissue Proteins, Prognosis, Small Cell Lung Carcinoma, Survival Rate, Tumor Biomarkers |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 10 |
| Number: | 1 |
| Page Range: | 3407 |
| Date: | 20 August 2019 |
| Official Publication: | https://doi.org/10.1038/s41467-019-11276-9 |
| PubMed: | View item in PubMed |
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