The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma

Item Type:	Article
Title:	The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
Creators Name:	Wagener, R. and Seufert, J. and Raimondi, F. and Bens, S. and Kleinheinz, K. and Nagel, I. and Altmüller, J. and Thiele, H. and Hübschmann, D. and Kohler, C.W. and Nürnberg, P. and Au-Yeung, R. and Burkhardt, B. and Horn, H. and Leoncini, L. and Jaffe, E.S. and Ott, G. and Rymkiewicz, G. and Schlesner, M. and Russell, R.B. and Klapper, W. and Siebert, R.
Abstract:	The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each ≥3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL,11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level.
Keywords:	Burkitt-Like Lymphoma, Burkitt's Lymphoma, Genes, Mutation, Immunoglobulins, Lymphoma, Translocation (Genetics)
Source:	Blood
ISSN:	0006-4971
Publisher:	American Society of Hematology
Volume:	133
Number:	9
Page Range:	962-966
Date:	28 February 2019
Official Publication:	https://doi.org/10.1182/blood-2018-07-864025
PubMed:	View item in PubMed

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