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Role of CMR imaging in diagnostics and evaluation of cardiac involvement in muscle dystrophies

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Item Type:Review
Title:Role of CMR imaging in diagnostics and evaluation of cardiac involvement in muscle dystrophies
Creators Name:Blaszczyk, E. and Gröschel, J. and Schulz-Menger, J.
Abstract:PURPOSE OF REVIEW: This review aims to outline the utility of cardiac magnetic resonance (CMR) in patients with different types of muscular dystrophies for the assessment of myocardial involvement, risk stratification and in guiding therapeutic decisions. RECENT FINDINGS: In patients suffering from muscular dystrophies (MD), even mild initial dysfunction may lead to severe heart failure over a time course of years. CMR plays an increasing role in the diagnosis and clinical care of these patients, mostly due to its unique capability to precisely characterize subclinical and progressive changes in cardiac geometry, function in order to differentiate myocardial injury it allows the identification of inflammation, focal and diffuse fibrosis as well as fatty infiltration. CMR may provide additional information in addition to the physical examination, laboratory tests, ECG, and echocardiography. SUMMARY: Further trials are needed to investigate the potential impact of CMR on the therapeutic decision-making as well as the assessment of long-term prognosis in different forms of muscular dystrophies. In addition to the basic cardiovascular evaluation, CMR can provide a robust, non-invasive technique for the evaluation of subclinical myocardial tissue injury like fat infiltration and focal and diffuse fibrosis. Furthermore, CMR has a unique capability to detect the progression of myocardial tissue damage in patients with a preserved systolic function.
Keywords:Muscular Dystrophy, Cardiovascular Magnetic Resonance, Cardiac Involvement, Heart Failure, Fat, Fibrosis
Source:Current Heart Failure Reports
Publisher:Springer Nature
Page Range:211-224
Date:August 2021
Official Publication:https://doi.org/10.1007/s11897-021-00521-2
PubMed:View item in PubMed

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