Cognitive impairment in multiple system atrophy is related to white matter damage detected by the T1-weighted/T2-weighted ratio

Item Type:	Article
Title:	Cognitive impairment in multiple system atrophy is related to white matter damage detected by the T1-weighted/T2-weighted ratio
Creators Name:	Sugiyama, A. and Cooper, G. and Hirano, S. and Yokota, H. and Mori, M. and Shimizu, K. and Yakiyama, M. and Finke, C. and Brandt, A.U. and Paul, F. and Kuwabara, S.
Abstract:	INTRODUCTION: This study aimed to use a novel MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, to assess damage of the white matter and gray matter in multiple system atrophy (MSA). Furthermore, this study investigated whether the sT1w/T2w ratio was associated with cognitive impairment in MSA. METHODS: The white matter and gray matter sT1w/T2w ratio of 37 MSA patients and 19 healthy controls were measured. Correlation analyses were used to evaluate the relationship between sT1w/T2w ratio values and clinical variables, and a multivariate analysis was used to identify independent factors associated with cognitive impairment in MSA. RESULTS: MSA patients showed a higher white matter sT1w/T2w ratio value than controls (p < 0.001), and the white matter sT1w/T2w ratio value was significantly correlated with the International Cooperative Ataxia Rating Scale score (r = 0.377, p = 0.021) and the Addenbrooke’s cognitive examination III score (r = −0.438, p = 0.007). Cognitively impaired MSA patients had a significantly higher white matter sT1w/T2w ratio value than cognitively preserved MSA patients (p = 0.010), and the multiple logistic regression analysis revealed that the median white matter sT1w/T2w ratio value was independently associated with cognitive impairment in MSA. CONCLUSION: The sT1w/T2w ratio is sensitive to degenerative changes in the white matter that is associated with cognitive ability in MSA patients.
Keywords:	Multiple System Atrophy, Cognitive Dysfunction, Magnetic Resonance Imaging, Iron, White Matter
Source:	European Neurology
ISSN:	0014-3022
Publisher:	Karger
Volume:	84
Number:	6
Page Range:	435-443
Date:	November 2021
Official Publication:	https://doi.org/10.1159/000517360
PubMed:	View item in PubMed

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