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An executive center for the intake of liquids

Item Type:Preprint
Title:An executive center for the intake of liquids
Creators Name:Dempsey, B. and Sungeelee, S. and Bokiniec, P. and Chettouh, Z. and Diem, S. and Autran, S. and Harrell, E.R. and Poulet, J.F.A. and Birchmeier, C. and Carrey, H. and Genovesio, A. and McMullan, S. and Goridis, C. and Fortin, G. and Brunet, J.F.
Abstract:It has long been known that orofacial movements for feeding can be triggered, coordinated, and often rhythmically organized at the level of the brainstem, without input from higher centers. We uncover two nuclei that can organize the movements for ingesting fluids in mammals. These neuronal groups, defined by unique transcriptional codes and developmental origins, IRt(Phox2b) and Peri5(Atoh1), are located, respectively, in the intermediate reticular formation of the medulla and around the motor nucleus of the trigeminal nerve. They are premotor to all jaw-opening and tongue muscles. Stimulation of either, in awake animals, opens the jaw, while IRt(Phox2b) alone also protracts the tongue. Moreover, stationary stimulation of IRt(Phox2b) entrains a rhythmic alternation of tongue protraction and retraction, synchronized with jaw opening and closing, that mimics lapping. Finally, fiber photometric recordings show that IRt(Phox2b) is active during volitional lapping. Our study identifies one of the long hypothesized subcortical nuclei underpinning a stereotyped feeding behavior.
Keywords:Animals, Mice
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2021.07.02.450862
Date:4 July 2021
Official Publication:https://doi.org/10.1101/2021.07.02.450862

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