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| Item Type: | Article |
|---|---|
| Title: | Breeding and maintenance of immunodeficient mouse lines under SPF conditions - a call for individualized severity analyses and approval procedures |
| Creators Name: | Kammertoens, T. and Jeuthe, S. and Baranzke, H. and Klippert, A. and Thöne-Reineke, C. |
| Abstract: | In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods are available. However, the breeding of immunodeficient mice is considered an experiment requiring a permit, even if no pain, suffering or harm is observed under scientifically required defined hygienic housing conditions, as determined by established methods of severity assessment. This seems contradictory and leads to uncertainty among scientists. With this commentary, we would like to shed light on this topic from different perspectives and propose a solution in terms of individualized severity assessment and approval procedures. |
| Keywords: | Immunodeficiency, Severity Assessment, Animal Experiment, 3R, Animals, Mice |
| Source: | Animals |
| ISSN: | 2076-2615 |
| Publisher: | MDPI |
| Volume: | 11 |
| Number: | 6 |
| Page Range: | 1789 |
| Date: | June 2021 |
| Official Publication: | https://doi.org/10.3390/ani11061789 |
| PubMed: | View item in PubMed |
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