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Neuromodulation and behavioral flexibility in larval zebrafish: from neurotransmitters to circuits

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Item Type:Review
Title:Neuromodulation and behavioral flexibility in larval zebrafish: from neurotransmitters to circuits
Creators Name:Corradi, L. and Filosa, A.
Abstract:Animals adapt their behaviors to their ever-changing needs. Internal states, such as hunger, fear, stress, and arousal are important behavioral modulators by controlling the way an organism perceives sensory stimuli and reacts to them. The translucent zebrafish larva is an ideal model organism for studying neuronal circuits regulating brain states, owning to the possibility of easy imaging and manipulating activity of genetically identified neurons while the animal performs stereotyped and well-characterized behaviors. The main neuromodulatory circuits present in mammals can also be found in the larval zebrafish brain, with the advantage that they contain small numbers of neurons. Importantly, imaging and behavioral techniques can be combined with methods for generating targeted genetic modifications to reveal the molecular underpinnings mediating the functions of such circuits. In this review we discuss how studying the larval zebrafish brain has contributed to advance our understanding of circuits and molecular mechanisms regulating neuromodulation and behavioral flexibility.
Keywords:Neuromodulation, Behavior, Neuronal Circuits, Flexibility, Foraging, Escape (Avoidance), Arousal, Animals, Zebrafish
Source:Frontiers in Molecular Neuroscience
Publisher:Frontiers Media SA
Page Range:718951
Date:15 July 2021
Official Publication:https://doi.org/10.3389/fnmol.2021.718951
PubMed:View item in PubMed

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