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Circulating HLA-G and its association with cardiovascular markers in pregnancy

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Item Type:Article
Title:Circulating HLA-G and its association with cardiovascular markers in pregnancy
Creators Name:Lekva, T. and Jacobsen, D.P. and Sugulle, M. and Moe, K. and Fjeldstad, H.E.S. and Dechend, R. and Staff, A.C.
Abstract:Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation.
Keywords:Preeclampsia, CVD, SRC, VEGFD, Multiplex
Source:Journal of Reproductive Immunology
Page Range:103331
Date:August 2021
Official Publication:https://doi.org/10.1016/j.jri.2021.103331
PubMed:View item in PubMed

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