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The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health

Item Type:Review
Title:The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health
Creators Name:Sun-Wang, J.L. and Yarritu-Gallego, A. and Ivanova, S. and Zorzano, A.
Abstract:Type 2 diabetes mellitus (T2DM) is a global health challenge. Therefore, understanding the molecular mechanisms underlying the pathophysiology of T2DM is key to improving current therapies. Loss of protein homeostasis leads to the accumulation of damaged proteins in cells, which results in tissue dysfunction. The elimination of damaged proteins occurs through the ubiquitin-proteasome system (UPS) and autophagy. In this review, we describe the mutual regulation between the UPS and autophagy and the involvement of these two proteolytic systems in metabolic dysregulation, insulin resistance, and T2DM. We propose that alterations in the UPS or autophagy contribute to triggering insulin resistance and the development of T2DM. In addition, these two pathways emerge as promising therapeutic targets for improving insulin resistance.
Keywords:Autophagy, Proteasome, Proteaphagy, E3-Ubiquitin Ligases, UPS-Autophagy Crosstalk
Source:Trends in Endocrinology and Metabolism
Page Range:594-608
Date:August 2021
Official Publication:https://doi.org/10.1016/j.tem.2021.04.015
PubMed:View item in PubMed

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