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A window into the future? MRI for evaluation of neuromyelitis optica spectrum disorder throughout the disease course

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Item Type:Review
Title:A window into the future? MRI for evaluation of neuromyelitis optica spectrum disorder throughout the disease course
Creators Name:Solomon, J.M. and Paul, F. and Chien, C. and Oh, J. and Rotstein, D.L.
Abstract:Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, inflammatory disease of the central nervous system marked by relapses often associated with poor recovery and long-term disability. Magnetic resonance imaging (MRI) is recognized as an important tool for timely diagnosis of NMOSD as, in combination with serologic testing, it aids in distinguishing NMOSD from possible mimics. Although the role of MRI for disease monitoring after diagnosis is not as well established, MRI may provide important prognostic information and help differentiate between relapses and pseudorelapses. Increasing evidence of subclinical disease activity and the emergence of newly approved, highly effective immunotherapies for NMOSD adjure us to re-evaluate MRI as a tool to guide optimal treatment selection and escalation throughout the disease course. In this article we review the role of MRI in NMOSD diagnosis, prognostication, disease monitoring, and treatment selection.
Keywords:Disease Activity, MRI, NMOSD, Prognosis
Source:Therapeutic Advances in Neurological Disorders
ISSN:1756-2856
Publisher:Sage Publications
Volume:14
Page Range:175628642110143
Date:9 May 2021
Official Publication:https://doi.org/10.1177/17562864211014389
PubMed:View item in PubMed

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