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| Item Type: | Article |
|---|---|
| Title: | AQP4-IgG autoimmunity in Japan and Germany: differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders |
| Creators Name: | Asseyer, S. and Masuda, H. and Mori, M. and Bellmann-Strobl, J. and Ruprecht, K. and Siebert, N. and Cooper, G. and Chien, C. and Duchow, A. and Schließeit, J. and Liu, J. and Sugimoto, K. and Uzawa, A. and Ohtani, R. and Paul, F. and Brandt, A.U. and Kuwabara, S. and Zimmermann, H.G. |
| Abstract: | BACKGROUND: Clinical outcomes in neuromyelitis optica spectrum disorders (NMOSD) vary across different regions. OBJECTIVE: To describe clinical profiles in Japanese and German NMOSD patients. METHODS: Medical records of aquaporin-4-immunoglobulin G (AQP4-IgG) positive NMOSD patients from Japan (n = 54) and Germany (n = 38) were retrospectively analyzed. RESULTS: The disability status was similar between both cohorts, although Japanese patients had a longer disease duration (13.3 ± 11.1 vs. 8.1 ± 6.9 years, p = 0.018) but similar relapse rates. Optic neuritis and myelitis were the most frequent attacks in both cohorts. Brain attacks occurred more frequently in Japanese patients (40.7% vs. 15.8%, p = 0.020). The time from disease onset (median [interquartile range] 2.3 [0.3-10.1] vs. 0.6 [0.2-1.9] years, p = 0.009) and the number of attacks (2.5 [1-7] vs. 2 [1-3], p = 0.047) until start of the first immunotherapy were higher in the Japanese cohort. Rituximab was the most common drug in the German cohort (52.6%) and not given in the Japanese cohort (p < 0.001), where oral prednisolone was the most common drug (92.6% vs. 15.8%, p < 0.001). The frequency of autoimmune comorbidities was higher in the German cohort (39.5% vs. 18.5%, p = 0.047). CONCLUSION: Compared with Japanese NMOSD patients, German patients presented with similar disability despite shorter disease duration and earlier and more frequent immunosuppressive therapy. |
| Keywords: | Anti-Aquaporin 4 Antibodies, Autoimmune Diseases, Ethnicity, Immunotherapy, Neuromyelitisoptica Spectrum Disorders |
| Source: | Multiple Sclerosis Journal Experimental Translational and Clinical |
| ISSN: | 2055-2173 |
| Publisher: | Sage Publications |
| Volume: | 7 |
| Number: | 2 |
| Page Range: | 205521732110068 |
| Date: | 1 April 2021 |
| Official Publication: | https://doi.org/10.1177/20552173211006862 |
| PubMed: | View item in PubMed |
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