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Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

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Item Type:Article
Title:Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Creators Name:Dyring-Andersen, B. and Løvendorf, M.B. and Coscia, F. and Santos, A. and Møller, L.B.P. and Colaço, A.R. and Niu, L. and Bzorek, M. and Doll, S. and Andersen, J.L. and Clark, R.A. and Skov, L. and Teunissen, M.B.M. and Mann, M.
Abstract:Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combine advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantify 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe the quantitative distribution of structural proteins, known and previously undescribed proteins specific to cellular subsets and those with specialized immunological functions such as cytokines and chemokines. We anticipate that this proteomic atlas of human skin will become an essential community resource for basic and translational research (https://skin.science/).
Keywords:Biomarkers, Cultured Cells, Proteome, Proteomics, Skin
Source:Nature Communications
Publisher:Nature Publishing Group
Page Range:5587
Date:5 November 2020
Official Publication:https://doi.org/10.1038/s41467-020-19383-8
PubMed:View item in PubMed

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