Helmholtz Gemeinschaft


Phenylalanine-hydroxylase contributes to serotonin synthesis in mice

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supporting Information)

Item Type:Article
Title:Phenylalanine-hydroxylase contributes to serotonin synthesis in mice
Creators Name:Mordhorst, A. and Dhandapani, P. and Matthes, S. and Mosienko, V. and Rothe, M. and Todiras, M. and Self, J. and Schunck, W.H. and Schütz, A. and Bader, M. and Alenina, N.
Abstract:Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate‐limiting step of its synthesis. In most vertebrates, two enzymes have been described to catalyze this step, tryptophan hydroxylase (TPH) 1 and 2, with expression localized to peripheral and neuronal cells, respectively. However, animals lacking both TPH isoforms still exhibit about 10% of normal serotonin levels in the blood demanding an additional source of the monoamine. In this study, we provide evidence by the gain and loss of function approaches in in vitro and in vivo systems, including stable‐isotope tracing in mice, that phenylalanine hydroxylase (PAH) is a third TPH in mammals. PAH contributes to serotonin levels in the blood, and may be important as a local source of serotonin in organs in which no other TPHs are expressed, such as liver and kidney.
Keywords:Phenylalanine Hydroxylase, Serotonin, Tryptophan Hydroxylase, Animals, Mice
Source:FASEB Journal
Publisher:Federation of American Societies for Experimental Biology
Page Range:e21648
Date:June 2021
Official Publication:https://doi.org/10.1096/fj.202100366R
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library