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Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation

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Item Type:Article
Title:Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation
Creators Name:Cooper, G. and Chien, C. and Zimmermann, H. and Bellmann-Strobl, J. and Ruprecht, K. and Kuchling, J. and Asseyer, S. and Brandt, A.U. and Scheel, M. and Finke, C. and Paul, F.
Abstract:BACKGROUND: Cross-sectional studies suggest normal appearing white matter (NAWM) integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis (MS). OBJECTIVE: To investigate the relationship between NAWM integrity and cortical thickness from first clinical presentation longitudinally. METHODS: NAWM integrity and cortical thickness were assessed with 3T magnetic resonance imaging (MRI) in 102 patients with clinically isolated syndrome or early MS (33.2 (20.1–60.1) years old, 68% female) from first clinical presentation over 2.8 ± 1.6 years. Fifty healthy controls (HCs) matched for age and sex were included. NAWM integrity was evaluated using the standardized T1w/T2w ratio (sT1w/T2w). The association between sT1w/T2w and cortical thickness was assessed using linear mixed models. The effect of disease activity was investigated using the No Evidence of Disease Activity (NEDA-3) criteria. RESULTS: At baseline, sT1w/T2w (p = 0.152) and cortical thickness (p = 0.489) did not differ from HCs. Longitudinally, decreasing sT1w/T2w was associated with cortical thickness and increasing lesion burden (marginal R(2) = 0.061). The association was modulated by failing NEDA-3 (marginal R(2) = 0.097). CONCLUSION: sT1w/T2w may be a useful MRI biomarker for early MS, detecting relevant NAWM damage over time using conventional MRI scans, although with less sensitivity compared to quantitative measures.
Keywords:T1w/T2w Ratio, Multiple Sclerosis, Normal Appearing White Matter Damage, Cortical Thickness, Longitudinal Analysis, NEDA-3
Source:Multiple Sclerosis Journal
Publisher:Sage Publications
Page Range:2180-2190
Date:December 2021
Official Publication:https://doi.org/10.1177/13524585211003479
PubMed:View item in PubMed

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