Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Uncharted biosynthetic potential of the ocean microbiome

Item Type:Preprint
Title:Uncharted biosynthetic potential of the ocean microbiome
Creators Name:Paoli, L. and Ruscheweyh, H.J. and Forneris, C.C. and Kautsar, S. and Clayssen, Q. and Salazar, G. and Milanese, A. and Gehrig, D. and Larralde, M. and Carroll, L.M. and Sánchez, P. and Zayed, A.A. and Cronin, D.R. and Acinas, S.G. and Bork, P. and Bowler, C. and Delmont, T.O. and Sullivan, M.B. and Wincker, P. and Zeller, G. and Robinson, S.L. and Piel, J. and Sunagawa, S.
Abstract:SUMMARY: Microbes are phylogenetically and metabolically diverse. Yet capturing this diversity, assigning functions to host organisms and exploring the biosynthetic potential in natural environments remains challenging. We reconstructed >25,000 draft genomes, including from >2,500 uncharacterized species, from globally-distributed ocean microbial communities, and combined them with ∼10,000 genomes from cultivated and single cells. Mining this resource revealed ∼40,000 putative biosynthetic gene clusters (BGCs), many from unknown phylogenetic groups. Among these, we discovered Candidatus Eudoremicrobiaceae as one of the most biosynthetically diverse microbes detected to date. Discrete transcriptional states structuring natural populations were associated with a potentially niche-partitioning role for BGC products. Together with the characterization of the first Eudoremicrobiaceae natural product, this study demonstrates how microbiomics enables prospecting for candidate bioactive compounds in underexplored microbes and environments.
Keywords:Ocean Microbiome, Genome-Resolved Microbiomics, Meta-Omics, Natural Products, Biosynthetical Potential, Candidatus Eudoremicrobiaceae, Candidatus Eudoremicrobium, Candidatus Amphithoemicrobium, Candidatus Autonoemicrobium
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2021.03.24.436479
Date:24 March 2021
Official Publication:https://doi.org/10.1101/2021.03.24.436479

Repository Staff Only: item control page

Open Access
MDC Library