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Single-cell genomics to study developmental cell fate decisions in zebrafish

Item Type:Review
Title:Single-cell genomics to study developmental cell fate decisions in zebrafish
Creators Name:Moreno-Ayala, R. and Junker, J.P.
Abstract:New developments in single-cell genomics have transformed developmental biology in recent years by enabling systematic analysis of embryonic cell types and differentiation trajectories. Ongoing efforts in experimental and computational method development aim to reveal gene-regulatory mechanisms and to provide additional spatio-temporal information about developmental cell fate decisions. Here, we discuss recent technological developments as well as biological applications of single-cell genomics, with a particular focus on analysis of developmental cell fate decisions. Although the approaches described here are generally applicable to a broad range of model systems, we focus our discussion on applications in zebrafish, which has proven to be a particularly powerful model organism for establishing novel methods in single-cell genomics.
Keywords:Cell Fate Decisions, Development, Single-Cell Genomics, Spatial Transcriptomics, Lineage Tracing, Animals, Zebrafish
Source:Briefings in Functional Genomics
ISSN:2041-2649
Publisher:Oxford University Press
Volume:20
Number:6
Page Range:420–426
Date:November 2021
Official Publication:https://doi.org/10.1093/bfgp/elab018
PubMed:View item in PubMed

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