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Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: a longitudinal study

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Item Type:Article
Title:Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: a longitudinal study
Creators Name:Papadopoulou, A. and Oertel, F.C. and Chien, C. and Kuchling, J. and Zimmermann, H.G. and Siebert, N. and Motamedi, S. and D'Souza, M. and Asseyer, S. and Bellmann-Strobl, J. and Ruprecht, K. and Chakravarty, M.M. and Scheel, M. and Magon, S. and Wuerfel, J. and Paul, F. and Brandt, A.U.
Abstract:OBJECTIVES: Lateral geniculate nucleus (LGN) volume is reduced after optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD). We aimed at a longitudinal assessment of LGN volume in NMOSD. METHODS: Twenty-nine patients with aquaporin 4-IgG seropositive NMOSD (age: 47.8 ± 14.6 years (y), female: n = 27, history of ON (NMO-ON): n = 17, median time since ON: 3[1.2-12.1]y) and 18 healthy controls (HC; age: 39.3 ± 15.8y; female: n = 13) were included. Median follow-up was 4.1[1.1-4.7]y for patients and 1.7[0.9-3.2]y for HC. LGN volume was measured using a multi-atlas-based approach of automated segmentation on 3 Tesla magnetic resonance images. Retinal optical coherence tomography and probabilistic tractography of the optic radiations (OR) were also performed. RESULTS: At baseline, NMO-ON patients had lower LGN volumes (395.4 ± 48.9 mm(3)) than patients without ON (NMO-NON: 450.7 ± 55.6 mm(3); p = 0.049) and HC (444.5 ± 61.5 mm(3), p = 0.025). LGN volume was associated with retinal neuroaxonal loss and microstructural OR damage. Longitudinally, there was no change in LGN volumes in the absence of ON, neither in all patients (B = -0.6, SE = 1.4, p = 0.670), nor in NMO-ON (B = -0.8, SE = 1.6, p = 0.617) and NMO-NON (B = 1.7, SE = 3.5, p = 0.650). However, in four patients with new ON during follow-up, LGN volume was reduced at last visit (median time since ON: 2.6 [1.8-3.9]y) compared to the measurement before ON (352 ± 52.7 vs. 371.1 ± 55.9 mm(3); t = -3.6, p = 0.036). CONCLUSION: Although LGN volume is reduced after ON in NMOSD, this volume loss is not progressive over longer follow-up or independent of ON. Thus, our findings -at least in this relatively small cohort- do not support occult neurodegeneration of the afferent visual pathway in NMOSD.
Keywords:Thalamus, Neurodegeneration, NMOSD, Anterograde Degeneration
Source:NeuroImage: Clinical
Page Range:102608
Date:4 March 2021
Official Publication:https://doi.org/10.1016/j.nicl.2021.102608
PubMed:View item in PubMed

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