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Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions

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Item Type:Preprint
Title:Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions
Creators Name:Coxam, B. and Padberg, Y. and Maier, K. and Jung, S. and Bartels-Klein, E. and Szymborska, A. and Finotto, L. and Schulte-Merker, S. and Gerhardt, H.
Abstract:We report the discovery that flow and Svep1 are modulator of vessel anastomosis during developmental angiogenesis in zebrafish embryos. We show that loss of Svep1 and blood flow reduction both contribute to defective anastomosis of intersegmental vessels. We show that this defect in primary angiogenic sprouts is associated with an expansion of Apelin-positive tip cells and with reduced formation and lumenisation of the dorsal longitudinal anastomotic vessel. Mechanistically, our results suggest that flow and Svep1 act synergistically to modulate vascular network formation in the zebrafish trunk.
Keywords:Animals, Zebrafish
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2021.03.13.435246
Date:19 March 2021
Official Publication:https://doi.org/10.1101/2021.03.13.435246
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https://edoc.mdc-berlin.de/21369/Final version

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