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Energy metabolites as biomarkers in ischemic and dilated cardiomyopathy

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Item Type:Article
Title:Energy metabolites as biomarkers in ischemic and dilated cardiomyopathy
Creators Name:Haas, J. and Frese, K.S. and Sedaghat-Hamedani, F. and Kayvanpour, E. and Tappu, R. and Nietsch, R. and Tugrul, O.F. and Wisdom, M. and Dietrich, C. and Amr, A. and Weis, T. and Niederdränk, T. and Murphy, M.P. and Krieg, T. and Dörr, M. and Völker, U. and Fielitz, J. and Frey, N. and Felix, S.B. and Keller, A. and Katus, H.A. and Meder, B.
Abstract:With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10(-6)). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.
Keywords:Cardiomyopathy, Energy Metabolism, Heart Failure, Multi-Omics
Source:International Journal of Molecular Sciences
Page Range:1999
Date:18 February 2021
Official Publication:https://doi.org/10.3390/ijms22041999
PubMed:View item in PubMed

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