Helmholtz Gemeinschaft


Fasting alters the gut microbiome with sustained blood pressure and body weight reduction in metabolic syndrome patients

PDF (Preprint) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supplementary Material)
Item Type:Preprint
Title:Fasting alters the gut microbiome with sustained blood pressure and body weight reduction in metabolic syndrome patients
Creators Name:Balogh, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
Abstract:Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. We show that in hypertensive metabolic syndrome (MetS) patients (n=35), a 5-day fast followed by a modified DASH diet (Dietary Approach to Stop Hypertension) reduced systolic blood pressure (SBP), antihypertensive medication need, and body-mass index (BMI) at three months post intervention compared to a modified DASH diet alone (n=36). Fasting altered the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses revealed a positive correlation of circulating mucosa-associated invariant T (MAIT) cells, non-classical monocytes and CD4+ effector T cells with SBP. Furthermore, regulatory T cells (Tregs) positively correlated with BMI and weight. Machine learning could predict sustained SBP-responsiveness within the fasting group from baseline immunome data, identifying CD8+ effector T cells, Th17 cells and Tregs as important contributors to the model. The high-resolution multi-omics data highlights fasting as a promising non-pharmacological intervention in MetS.
Keywords:Metabolic Syndrome, Hypertension, Periodic Fasting, Microbiome, Immunome
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2020.02.23.20027029
Date:25 February 2020
Official Publication:https://doi.org/10.1101/2020.02.23.20027029
Related to:
https://edoc.mdc-berlin.de/20045/Final version

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library