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Olig3 regulates early cerebellar development

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Item Type:Article
Title:Olig3 regulates early cerebellar development
Creators Name:Lowenstein, E.D. and Rusanova, A. and Stelzer, J. and Hernaiz-Llorens, M. and Schroer, A.E. and Epifanova, E. and Bladt, F. and Isik, E.G. and Buchert, S. and Jia, S. and Tarabykin, V. and Hernandez-Miranda, L.R.
Abstract:The mature cerebellum controls motor skill precision and participates in other sophisticated brain functions that include learning, cognition, and speech. Different types of GABAergic and glutamatergic cerebellar neurons originate in temporal order from two progenitor niches, the ventricular zone and rhombic lip, which express the transcription factors Ptf1a and Atoh1, respectively. However, the molecular machinery required to specify the distinct neuronal types emanating from these progenitor zones is still unclear. Here, we uncover the transcription factor Olig3 as a major determinant in generating the earliest neuronal derivatives emanating from both progenitor zones in mice. In the rhombic lip, Olig3 regulates progenitor cell proliferation. In the ventricular zone, Olig3 safeguards Purkinje cell specification by curtailing the expression of Pax2, a transcription factor that suppresses the Purkinje cell differentiation program. Our work thus defines Olig3 as a key factor in early cerebellar development.
Keywords:Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cerebellum, Developmental Gene Expression Regulation, Knockout Mice, Neurogenesis, Purkinje Cells, Transcription Factors, Animals, Mice
Publisher:eLife Sciences Publications
Page Range:e64684
Date:16 February 2021
Official Publication:https://doi.org/10.7554/eLife.64684
PubMed:View item in PubMed

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