The second cAMP messenger and cardiac function regulation: the role of adenylate cyclase [Il secondo messaggero cAMP e la regolazione della funzione cardiaca: ruolo dell'adenilato ciclasi]

Item Type:	Review
Title:	The second cAMP messenger and cardiac function regulation: the role of adenylate cyclase [Il secondo messaggero cAMP e la regolazione della funzione cardiaca: ruolo dell'adenilato ciclasi]
Creators Name:	Capretti, G. and Franzone, A. and Schiattarella, G.G. and Gargiulo, G. and Sannino, A. and Sorrentino, S. and Perrino, C. and Esposito, G. and Chiariello, M.
Abstract:	Cyclic adenosine monophosphate (cAMP) is the second messenger synthesized by adenylate cyclase (AC) inresponse to β-adrenergic receptor (βAR) stimulation. In normal conditions, cAMP plays an important role inregulating several cardiovascular functions, including heart rate and contractility. Several abnormalities in β-adrenergic signal transduction have been identified in heart failure and they are thought to be linked to thedecrease in cardiac contractility. Different mechanisms have been considered responsible for these alterations,including desensitization/down-regulation of βARs and decreases in AC5/AC6 levels, the major cardiac ACisoforms. Recently, several experimental studies have been performed on transgenic animals to clarify the roleof the different AC isoforms in normal conditions and during the development of left ventricular dysfunction.This review describes the results of the latest experiments based on the genetic manipulation of AC isoforms,and the new possible therapeutic strategies for treating heart failure which arise from them.
Keywords:	Heart Failure, Heart Function, Heart Left Ventricle Failure, Heart Muscle Contractility, Heart Rate, Receptor Down Regulation, Signal Transduction, Transgenic Animal, Animal
Source:	Trends in Medicine
ISSN:	1594-2848
Publisher:	Pharma Project Group
Volume:	9
Number:	3
Page Range:	129-136
Date:	July 2009

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