Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings

Item Type:	Review
Title:	Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings
Creators Name:	Perrino, C. and Gargiulo, G. and Pironti, G. and Franzone, A. and Scudiero, L. and De Laurentis, M. and Magliulo, F. and Ilardi, F. and Carotenuto, G. and Schiattarella, G.G. and Esposito, G.
Abstract:	Exercise adaptations result from a coordinated response of multiple organ systems, including cardiovascular, pulmonary, endocrine-metabolic, immunologic, and skeletal muscle. Among these, the cardiovascular system is the most directly affected by exercise, and it is responsible for many of the important acute changes occurring during physical training. In recent years, the development of animal models of pathological or physiological cardiac overload has allowed researchers to precisely analyze the complex cardiovascular responses to stress in genetically altered murine models of human cardiovascular disease. The intensity-controlled treadmill exercise represents a well-characterized model of physiological cardiac hypertrophy because of its ability to mimic the typical responses to exercise in humans. In this review, we describe cardiovascular adaptations to treadmill exercise in mice and the most important parameters that can be used to quantify such modifications. Moreover, we discuss how treadmill exercise can be used to perform physiological testing in mouse models of disease and to enlighten the role of specific signaling pathways on cardiac function.
Keywords:	Animal Models, Physiological Hypertrophy, Animals, Mice
Source:	American Journal of Physiology Heart and Circulatory Physiology
ISSN:	0363-6135
Publisher:	American Physiological Society
Volume:	300
Number:	6
Page Range:	H1983-H1989
Date:	June 2011
Official Publication:	https://doi.org/10.1152/ajpheart.00784.2010
PubMed:	View item in PubMed

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