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Use of statins in lower extremity artery disease: a review

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Item Type:Article
Title:Use of statins in lower extremity artery disease: a review
Creators Name:Gargiulo, G. and Giugliano, G. and Brevetti, L. and Sannino, A. and Schiattarella, G.G. and Serino, F. and Carbone, A. and Scudiero, F. and Ferrone, M. and Corrado, R. and Izzo, R. and Chiariotti, L. and Perrino, C. and Amato, B. and Trimarco, B. and Esposito, G.
Abstract:BACKGROUND: Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk. DESCRIPTION: It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached. CONCLUSIONS: Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.
Keywords:Simvastatin, Pravastatin, Statin Therapy, Pentoxifylline, Cilostazol
Source:BMC Surgery
Publisher:BioMed Central
Number:Suppl 1
Page Range:S15
Date:15 November 2012
Official Publication:https://doi.org/10.1186/1471-2482-12-S1-S15
PubMed:View item in PubMed

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