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Noninvasive renal perfusion measurement using arterial spin labeling (ASL) MRI: basic concept

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Item Type:Article
Title:Noninvasive renal perfusion measurement using arterial spin labeling (ASL) MRI: basic concept
Creators Name:Ku, M.C. and Fernández-Seara, M.A. and Kober, F. and Niendorf, T.
Abstract:The kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
Keywords:Magnetic Resonance Imaging (MRI), Renal, Perfusion, Arterial Spin Labeling (ASL), Kidney, Animals, Mice
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
Publisher:Springer / Humana Press
Page Range:229-239
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_13
PubMed:View item in PubMed
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