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Recommendations for preclinical renal MRI: a comprehensive open-access protocol collection to improve training, reproducibility, and comparability of studies

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Item Type:Article
Title:Recommendations for preclinical renal MRI: a comprehensive open-access protocol collection to improve training, reproducibility, and comparability of studies
Creators Name:Pohlmann, A. and Back, S.J. and Fekete, A. and Friedli, I. and Hectors, S. and Jerome, N.P. and Ku, M.C. and Longo, D.L. and Meier, M. and Millward, J.M. and Periquito, J.S. and Seeliger, E. and Serai, S.D and Waiczies, S. and Sourbron, S. and Laustsen, C. and Niendorf, T.
Abstract:Renal MRI holds incredible promise for making a quantum leap in improving diagnosis and care of patients with a multitude of diseases, by moving beyond the limitations and restrictions of current routine clinical practice. Clinical and preclinical renal MRI is advancing with ever increasing rapidity, and yet, aside from a few examples of renal MRI in routine use, it is still not good enough. Several roadblocks are still delaying the pace of progress, particularly inefficient education of renal MR researchers, and lack of harmonization of approaches that limits the sharing of results among multiple research groups.Here we aim to address these limitations for preclinical renal MRI (predominantly in small animals), by providing a comprehensive collection of more than 40 publications that will serve as a foundational resource for preclinical renal MRI studies. This includes chapters describing the fundamental principles underlying a variety of renal MRI methods, step-by-step protocols for executing renal MRI studies, and detailed guides for data analysis. This collection will serve as a crucial part of a roadmap toward conducting renal MRI studies in a robust and reproducible way, that will promote the standardization and sharing of data.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
Keywords:Magnetic Resonance Imaging (MRI), Kidney, Acute Kidney Injury, Chronickidney Disease, Training, Standardization
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
Publisher:Springer / Humana Press
Page Range:3-23
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_1
PubMed:View item in PubMed
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