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Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites

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Item Type:Article
Title:Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites
Creators Name:Philippot, C. and Griemsmann, S. and Jabs, R. and Seifert, G. and Kettenmann, H. and Steinhäuser, C.
Abstract:Thalamic astrocytes and oligodendrocytes are coupled via gap junctions and form panglial networks. Here, we show that these networks have a key role in energy supply of neurons. Filling an astrocyte or an oligodendrocyte in acute slices with glucose or lactate is sufficient to rescue the decline of stimulation-induced field post-synaptic potential (fPSP) amplitudes during extracellular glucose deprivation (EGD). In mice lacking oligodendroglial coupling, loading an astrocyte with glucose does not rescue the EGD-mediated loss of fPSPs. Monocarboxylate and glucose transporters are required for rescuing synaptic activity during EGD. In mice deficient in astrocyte coupling, filling of an oligodendrocyte with glucose does not rescue fPSPs during EGD. Our results demonstrate that, in the thalamus, astrocytes and oligodendrocytes are jointly engaged in delivering energy substrates for sustaining neuronal activity and suggest that oligodendrocytes exert their effect mainly by assisting astrocytes in metabolite transfer to the postsynapse.
Keywords:Thalamus, Astrocyte, Oligodendrocyte, Panglial Coupling, Metabolite Support, Animals, Mice
Source:Cell Reports
Publisher:Cell Press / Elsevier
Page Range:108642
Date:19 January 2021
Official Publication:https://doi.org/10.1016/j.celrep.2020.108642
PubMed:View item in PubMed

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