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SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications

Item Type:Editorial
Title:SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications
Creators Name:Ye, Q. and Lai, E.Y. and Luft, F.C. and Persson, P.B. and Mao, J.
Abstract:Angiotensin converting enzyme-2 (ACE-2) is the cell-surface receptor enabling viral uptake of corona virus 2019 (SARS-CoV-2), thus ACE-2 is a first step towards COVID-19 disease. ACE-2 is a metalloenzyme located primarily on the apical surface, and serves as the entry point also for other coronaviruses, including HCoV-NL63 and SARS-CoV. Throughout evolution, ACE-2 precedes renin, suggesting that ACE-2's role changed over time.
Keywords:Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, COVID-19, Cardiovascular Disease, Renin-Angiotensin System, SARS-CoV-2, Animals, Mice
Source:Acta Physiologica
ISSN:1748-1708
Publisher:Wiley
Volume:231
Number:4
Page Range:e13608
Date:April 2021
Official Publication:https://doi.org/10.1111/apha.13608
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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