Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases

Item Type:	Article
Title:	Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases
Creators Name:	Schiattarella, G.G. and Sannino, A. and Esposito, G. and Perrino, C.
Abstract:	Alterations in gut microbiota composition and its metabolic activity are emerging as one of the most powerful determinants of cardiovascular disease. Although our knowledge of the precise molecular mechanisms by which gut microbiota influences cardiometabolic homeostasis is still limited, a growing body of knowledge has recently been uncovered about the potential modulation of microbiome for cardiovascular diagnostic and therapeutic aspects. The multitude of interactions between the microorganisms inhabiting the digestive tract and the host has been recognized crucial in the development and progression of atherosclerosis, obesity, diabetes and hypertension. Here, we summarize the role of gut microbiota in host physiology as well as in the pathophysiology of the most common cardio-metabolic disorders, discussing the potential therapeutic opportunities offered by interventions aimed at modifying microbiome composition and activity.
Keywords:	Cardiovascular Risk, Heart Failure, Metagenomics, Microbiome, Diet, Trimethylamine N-Oxide, Animals
Source:	Trends in Cardiovascular Medicine
ISSN:	1050-1738
Publisher:	Elsevier
Volume:	29
Number:	3
Page Range:	141-147
Date:	April 2019
Official Publication:	https://doi.org/10.1016/j.tcm.2018.08.003
PubMed:	View item in PubMed

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