Helmholtz Gemeinschaft


Bradykinin receptors

Item Type:Book Section
Title:Bradykinin receptors
Creators Name:Maghsodi, S. and Qadri, F. and Bader, M.
Abstract:Kinins, such as bradykinin and kallidin, are peptides generated from kininogen precursor proteins by the action of kallikreins. Plasma and tissue kallikrein are responsible for their synthesis in blood and tissues, respectively. While bradykinin and kallidin activate the bradykinin B2 receptor, carboxypeptidases generate truncated peptides, which are agonists of the B1 receptor. Both receptors are G-protein coupled. The B1 receptor is unique in being strongly upregulated under inflammatory conditions. Activation of kinin receptors elicits vasodilation, edema, smooth muscle contraction and pain, and thereby contributes to inflammatory diseases. B2 receptor antagonists are clinically used to stop angioedema attacks.
Keywords:B1 Receptor, B2 Receptor, Bradykinin, Icatibant, Inflammation, Kallidin, Kallikrein, Kininogen, Kinins
Source:Reference Module in Life Sciences
Series Name:Encyclopedia of Biological Chemistry III (Third Edition)
Title of Book:Reference Module in Life Sciences
Page Range:142-160
Official Publication:https://doi.org/10.1016/B978-0-12-819460-7.00097-9

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