Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Item Type:	Editorial
Title:	Trained immunity, tolerance, priming and differentiation: distinct immunological processes
Creators Name:	Divangahi, M. and Aaby, P.r and Khader, S.A. and Barreiro, L.B. and Bekkering, S. and Chavakis, T. and van Crevel, R. and Curtis, N. and DiNardo, A.R. and Dominguez-Andres, J. and Duivenvoorden, R. and Fanucchi, S. and Fayad, Z. and Fuchs, E. and Hamon, M. and Jeffrey, K.L. and Khan, N. and Joosten, L.A.B. and Kaufmann, E. and Latz, E. and Matarese, G. and van der Meer, J.W.M. and Mhlanga, M. and Moorlag, S.J.C.F.M. and Mulder, W.J.M. and Naik, S. and Novakovic, B. and O'Neill, L. and Ochando, J. and Ozato, K. and Riksen, N.P. and Sauerwein, R. and Sherwood, E.R. and Schlitzer, A. and Schultze, J.L. and Sieweke, M.H. and Benn, C.S. and Stunnenberg, H. and Sun, J. and van de Veerdonk, F.L. and Weis, S. and Williams, D.L. and Xavier, R. and Netea, M.G.
Abstract:	The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.
Keywords:	Adaptive Immunity, BCG Vaccine, Cell Differentiation, Immune Tolerance, Immunologic Memory, Innate Immunity, Vaccination, Animals
Source:	Nature Immunology
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Volume:	22
Number:	1
Page Range:	2-6
Date:	January 2021
Additional Information:	Erratum in: Nat Immunol 22(7): 928. Copyright © 2020, Springer Nature America, Inc.
Official Publication:	https://doi.org/10.1038/s41590-020-00845-6
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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