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USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans

Item Type:Article
Title:USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans
Creators Name:Schwaller, F. and Bégay, V. and García-García, G. and Taberner, F.J. and Moshourab, R. and McDonald, B. and Docter, T. and Kühnemund, J. and Ojeda-Alonso, J. and Paricio-Montesinos, R. and Lechner, S.G. and Poulet, J.F.A. and Millan, J.M. and Lewin, G.R.
Abstract:Fingertip mechanoreceptors comprise sensory neuron endings together with specialized skin cells that form the end-organ. Exquisitely sensitive, vibration-sensing neurons are associated with Meissner's corpuscles in the skin. In the present study, we found that USH2A, a transmembrane protein with a very large extracellular domain, was found in terminal Schwann cells within Meissner's corpuscles. Pathogenic USH2A mutations cause Usher's syndrome, associated with hearing loss and visual impairment. We show that patients with biallelic pathogenic USH2A mutations also have clear and specific impairments in vibrotactile touch perception, as do mutant mice lacking USH2A. Forepaw rapidly adapting mechanoreceptors innervating Meissner's corpuscles, recorded from Ush2a(-/-) mice, showed large reductions in vibration sensitivity. However, the USH2A protein was not found in sensory neurons. Thus, loss of USH2A in corpuscular end-organs reduced mechanoreceptor sensitivity as well as vibration perception. Thus, a tether-like protein is required to facilitate detection of small-amplitude vibrations essential for the perception of fine-grained tactile surfaces.
Keywords:Extracellular Matrix Proteins, Inbred CBA Mice, Knockout Mice, Mechanoreceptors, Mutation, Schwann Cells, Sensation, Skin, Touch, Usher Syndromes, Vibration, Animals, Mice
Source:Nature Neuroscience
Publisher:Nature Publishing Group
Page Range:74-81
Date:January 2021
Official Publication:https://doi.org/10.1038/s41593-020-00751-y
PubMed:View item in PubMed
Related to:
https://edoc.mdc-berlin.de/19100/Preprint version

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