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| Item Type: | Article |
|---|---|
| Title: | The needle in the haystack - searching for genetic and epigenetic differences in monozygotic twins discordant for Tetralogy of Fallot |
| Creators Name: | Grunert, M. and Appelt, S. and Grossfeld, P. and Sperling, S.R. |
| Abstract: | Congenital heart defects (CHDs) are the most common birth defect in human with an incidence of almost 1% of all live births. Most cases have a multifactorial origin with both genetics and the environment playing a role in its development and progression. Adding an epigenetic component to this aspect is exemplified by monozygotic twins which share the same genetic background but have a different disease status. As a result, the interplay between the genetic, epigenetic and the environmental conditions might contribute to the etiology and phenotype. To date, the underlying causes of the majority of CHDs remain poorly understood. In this study, we performed genome-wide high-throughput sequencing to examine the genetic, structural genomic and epigenetic differences of two identical twin pairs discordant for Tetralogy of Fallot (TOF), representing the most common cyanotic form of CHDs. Our results show the almost identical genetic and structural genomic identity of the twins. In contrast, several epigenetic alterations could be observed given by DNA methylation changes in regulatory regions of known cardiac-relevant genes. Overall, this study provides first insights into the impact of genetic and especially epigenetic factors underlying monozygotic twins discordant for CHD like TOF. |
| Keywords: | Congenital Heart Disease, Tetralogy of Fallot, Monozygotic Twins, Discordant Phenotype, Genetics, Variations, Epigenetics, DNA Methylation, Candidate Genes |
| Source: | Journal of Cardiovascular Development and Disease |
| ISSN: | 2308-3425 |
| Publisher: | MDPI |
| Volume: | 7 |
| Number: | 4 |
| Page Range: | 55 |
| Date: | 2 December 2020 |
| Official Publication: | https://doi.org/10.3390/jcdd7040055 |
| PubMed: | View item in PubMed |
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