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Distinctive patterns of inflammation across the heart failure syndrome

Item Type:Article
Title:Distinctive patterns of inflammation across the heart failure syndrome
Creators Name:Schiattarella, G.G. and Sequeira, V. and Ameri, P.
Abstract:Inflammation has long been known to play a role in heart failure (HF). Earlier studies demonstrated that inflammation contributes to the pathogenesis of HF with reduced ejection fraction (HFrEF), and the knowledge about molecules and cell types specifically involved in inflammatory events has been constantly increased ever since. However, conflicting results of several trials with anti-inflammatory treatments led to the conclusions that inflammation does participate in the progression of HFrEF, but more likely it is not the primary event. Conversely, it has been suggested that inflammation drives the development of HF with preserved ejection fraction (HFpEF). Recently the pharmacological blockade of interleukin-1 has been shown to prevent HF hospitalization and mortality in patients with prior myocardial infarction, lending renewed support to the hypothesis that inflammation is a promising therapeutic target in HF. Inflammation has also been proposed to underlie both HF and commonly associated conditions, such as chronic kidney disease or cancer. Within this last paradigm, an emergent role has been ascribed to clonal hematopoiesis of indeterminate potential. Here, we summarize the recent evidence about the role of inflammation in HF, highlighting the similarities and differences in HFrEF vs. HFpEF, and discuss the diagnostic and therapeutic opportunities raised by antinflammatory-based approaches.
Keywords:Heart Failure, Inflammation, Cytokines, Pathogenesis, Comorbidities
Source:Heart Failure Reviews
Page Range:1333–1344
Date:November 2020
Official Publication:https://doi.org/10.1007/s10741-020-09949-5
PubMed:View item in PubMed

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