Immunoglobulins G modulate endothelial function and affect insulin sensitivity in humans

Item Type:	Article
Title:	Immunoglobulins G modulate endothelial function and affect insulin sensitivity in humans
Creators Name:	Napoli, R. and Ruvolo, A. and Triggianese, P. and Prevete, N. and Schiattarella, G.G. and Nigro, C. and Miele, C. and Magliulo, F. and Grassi, S. and Pecoraro, A. and Cittadini, A. and Esposito, G. and de Paulis, A. and Spadaro, G.
Abstract:	BACKGROUND AND AIMS: Data from animals suggest that immunoglobulins G (IgG) play a mechanistic role in atherosclerosis and diabetes through endothelial dysfunction and insulin resistance. Patients with common variable immunodeficiency (CVID), who have low circulating levels of IgG and are treated with intravenous polyclonal IgG (IVIgG), may provide an ideal model to clarify whether circulating IgG modulate endothelial function and affect insulin sensitivity in humans. METHODS AND RESULTS: We studied 24 patients with CVID and 17 matched healthy controls (HC). Endothelial function was evaluated as flow mediated dilation (FMD) of the brachial artery at baseline and 1, 7, 14, and 21 days after IVIgG infusion in the CVID patients. We measured also plasma glucose, insulin, and calculated the HOMA-IR index. We also investigated the role of human IgG on the production of Nitric Oxide (NO) in vitro in Human Coronary Artery Endothelial Cells (HCAEC). Compared to HC, FMD of CVID patients was significantly impaired at baseline (9.4 ± 0.9 and 7.6 ± 0.6% respectively, p < 0.05) but rose above normal levels 1 and 7 days after IVIgG infusion to return at baseline at 14 and 21 days. Serum insulin concentration and HOMA-IR index dropped by 50% in CVID patients after IVIgG (p < 0.002 vs. baseline). In vitro IgG stimulated NO production in HCAEC. CONCLUSIONS: Reduced IgG levels are associated with endothelial dysfunction and IVIgG stimulates endothelial function directly while improving insulin sensitivity. The current findings may suggest an anti-atherogenic role of human IgG.
Keywords:	Atherosclerosis, Endothelial Function, Flow Mediated Dilation, Immunoglobulins, Insulin Resistance
Source:	Nutrition Metabolism and Cardiovascular Diseases
ISSN:	0939-4753
Publisher:	Elsevier
Volume:	30
Number:	11
Page Range:	2085-2092
Date:	30 October 2020
Official Publication:	https://doi.org/10.1016/j.numecd.2020.07.001
PubMed:	View item in PubMed

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