Linking structural biology with genome research: Beamlines for the Berlin "Protein Structure Factory" initiative

Item Type:	Conference or Workshop Item
Title:	Linking structural biology with genome research: Beamlines for the Berlin "Protein Structure Factory" initiative
Creators Name:	Illing, G. and Saenger, W. and Heinemann, U.
Abstract:	The Protein Structure Factory will be established to characterize proteins encoded by human genes or cDNAs, which will be selected by criteria of potential structural novelty or medical or biotechnological usefulness. It represents an integrative approach to structure analysis combining bioinformatics techniques, automated gene expression and purification of gene products, generation of a biophysical fingerprint of the proteins and the determination of their three-dimensional structures either by NMR spectroscopy or by X-ray diffraction. The use of synchrotron radiation will be crucial to the Protein Structure Factory: high brilliance and tunable wavelengths are prerequisites for fast data collection, the use of small crystals and multiwavelength anomalous diffraction (MAD) phasing. With the opening of BESSY II, direct access to a third-generation XUV storage ring source with excellent conditions is available nearby. An insertion device with two MAD beamlines and one constant energy station will be set up until 2001.
Source:	AIP Conference Proceedings
ISSN:	0094-243X
ISBN:	978-156396941-6
Publisher:	American Institute of Physics
Volume:	521
Page Range:	174-177
Date:	26 June 2000
Official Publication:	https://doi.org/10.1063/1.1291780

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