Solute excretion, metabolism, and cardio-renoprotection via two distinct mechanisms revolutionize clinical outcomes

Item Type:	Editorial
Title:	Solute excretion, metabolism, and cardio-renoprotection via two distinct mechanisms revolutionize clinical outcomes
Creators Name:	Luft, F.C.
Abstract:	Two pharmacological principles, one at least 80 years old and another over 60 years old have recently come to fruition. The first, phlorizin, was thought to cause diabetes, but then a closer look revealed a renal mechanism that was independent of insulin or insulin deficiency. Research into its action facilitated the discovery of sodium-dependent glucose transporters. The second compound came close on the heels of the discovery that the mineralocorticoid, aldosterone, can be released through the action of angiotensin II.
Keywords:	SGLT2, Mineralocorticoid Recepter, Finerenone, Cardiovascular Disease, Chronic Kidney Disease
Source:	Acta Physiologica
ISSN:	1748-1708
Publisher:	Wiley
Volume:	232
Number:	3
Page Range:	e13589
Date:	6 July 2021
Official Publication:	https://doi.org/10.1111/apha.13589
PubMed:	View item in PubMed

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