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Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany

Item Type:Article
Title:Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany
Creators Name:Liu, J. and Mori, M. and Zimmermann, H. and Brandt, A. and Havla, J. and Tanaka, S. and Sugimoto, K. and Oji, S. and Uzawa, A. and Asseyer, S. and Cooper, G. and Jarius, S. and Bellmann-Strobl, J. and Ruprecht, K. and Siebert, N. and Masuda, H. and Uchida, T. and Ohtani, R. and Nomura, K. and Meinl, E. and Kuempfel, T. and Paul, F. and Kuwabara, S.
Abstract:BACKGROUND: Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. OBJECTIVE: The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associated disorders between East Asian (Japanese) and Caucasian (German) patients. METHODS: Demographic, clinical and therapeutic data from 68 MOG-IgG-positive adults were collected (Japanese, n=44; German, n=24). RESULTS: Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%; German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019; no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0; p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%). CONCLUSIONS: Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity.
Source:Journal of Neurology Neurosurgery and Psychiatry
Publisher:BMJ Publishing Group
Page Range:377-383
Date:April 2021
Official Publication:https://doi.org/10.1136/jnnp-2020-324422
PubMed:View item in PubMed

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