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Sarcoma treatment in the era of molecular medicine

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Item Type:Review
Title:Sarcoma treatment in the era of molecular medicine
Creators Name:Grünewald, T.G.P. and Alonso, M. and Avnet, S. and Banito, A. and Burdach, S. and Cidre-Aranaz, F. and Di Pompo, G. and Distel, M. and Dorado-Garcia, H. and Garcia-Castro, J. and González-González, L. and Grigoriadis, A.E. and Kasan, M. and Koelsche, C. and Krumbholz, M. and Lecanda, F. and Lemma, S. and Longo, D.L. and Madrigal-Esquivel, C. and Morales-Molina, Á. and Musa, J. and Ohmura, S. and Ory, B. and Pereira-Silva, M. and Perut, F. and Rodriguez, R. and Seeling, C. and Al Shaaili, N. and Shaabani, S. and Shiavone, K. and Sinha, S. and Tomazou, E.M. and Trautmann, M. and Vela, M. and Versleijen-Jonkers, Y.M.H. and Visgauss, J. and Zalacain, M. and Schober, S.J. and Lissat, A. and English, W.R. and Baldini, Ni. and Heymann, D.
Abstract:Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
Source:EMBO Molecular Medicine
Page Range:e11131
Date:6 November 2020
Official Publication:https://doi.org/10.15252/emmm.201911131
PubMed:View item in PubMed

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