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| Item Type: | Letter |
|---|---|
| Title: | Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure |
| Creators Name: | Michalick, L., Weidenfeld, S., Grimmer, B., Fatykhova, D., Solymosi, P.D., Behrens, F., Dohmen, M., Brack, M.C., Schulz, S., Thomasch, E., Simmons, S., Müller-Redetzky, H., Suttorp, N., Kurth, F., Neudecker, J., Toennies, M., Bauer, T.T., Eggeling, S., Corman, V.M., Hocke, A.C., Witzenrath, M., Hippenstiel, S. and Kuebler, W.M. |
| Abstract: | Plasma of COVID-19 patients induces pulmonary microvascular barrier failure which increases with disease severity. Here, we report a versatile high-throughput screening platform to test for involved plasma mediators and the therapeutic potential of barrier stabilising compounds. |
| Keywords: | Actins, CD Antigens, COVID-19, Cadherins, Capillary Permeability, Case-Control Studies, Electric Impedance, Endothelial Cells, Endothelium, Hospitalization, Lung, Microvessels, Occludin, Plasma, SARS-CoV-2, Severity of Illness Index |
| Source: | European Respiratory Journal |
| ISSN: | 0903-1936 |
| Publisher: | European Respiratory Society |
| Volume: | 57 |
| Number: | 3 |
| Page Range: | 2002384 |
| Date: | 11 March 2021 |
| Official Publication: | https://doi.org/10.1183/13993003.02384-2020 |
| PubMed: | View item in PubMed |
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