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Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

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Item Type:Letter
Title:Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Creators Name:Michalick, L. and Weidenfeld, S. and Grimmer, B. and Fatykhova, D. and Solymosi, P.D. and Behrens, F. and Dohmen, M. and Brack, M.C. and Schulz, S. and Thomasch, E. and Simmons, S. and Müller-Redetzky, H. and Suttorp, N. and Kurth, F. and Neudecker, J. and Toennies, M. and Bauer, T.T. and Eggeling, S. and Corman, V.M. and Hocke, A.C. and Witzenrath, M. and Hippenstiel, S. and Kuebler, W.M.
Abstract:Plasma of COVID-19 patients induces pulmonary microvascular barrier failure which increases with disease severity. Here, we report a versatile high-throughput screening platform to test for involved plasma mediators and the therapeutic potential of barrier stabilising compounds.
Keywords:Actins, CD Antigens, COVID-19, Cadherins, Capillary Permeability, Case-Control Studies, Electric Impedance, Endothelial Cells, Endothelium, Hospitalization, Lung, Microvessels, Occludin, Plasma, SARS-CoV-2, Severity of Illness Index
Source:European Respiratory Journal
Publisher:European Respiratory Society
Page Range:2002384
Date:11 March 2021
Official Publication:https://doi.org/10.1183/13993003.02384-2020
PubMed:View item in PubMed

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