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| Item Type: | Letter |
|---|---|
| Title: | Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure |
| Creators Name: | Michalick, L. and Weidenfeld, S. and Grimmer, B. and Fatykhova, D. and Solymosi, P.D. and Behrens, F. and Dohmen, M. and Brack, M.C. and Schulz, S. and Thomasch, E. and Simmons, S. and Müller-Redetzky, H. and Suttorp, N. and Kurth, F. and Neudecker, J. and Toennies, M. and Bauer, T.T. and Eggeling, S. and Corman, V.M. and Hocke, A.C. and Witzenrath, M. and Hippenstiel, S. and Kuebler, W.M. |
| Abstract: | Plasma of COVID-19 patients induces pulmonary microvascular barrier failure which increases with disease severity. Here, we report a versatile high-throughput screening platform to test for involved plasma mediators and the therapeutic potential of barrier stabilising compounds. |
| Keywords: | Actins, CD Antigens, COVID-19, Cadherins, Capillary Permeability, Case-Control Studies, Electric Impedance, Endothelial Cells, Endothelium, Hospitalization, Lung, Microvessels, Occludin, Plasma, SARS-CoV-2, Severity of Illness Index |
| Source: | European Respiratory Journal |
| ISSN: | 0903-1936 |
| Publisher: | European Respiratory Society |
| Volume: | 57 |
| Number: | 3 |
| Page Range: | 2002384 |
| Date: | 11 March 2021 |
| Official Publication: | https://doi.org/10.1183/13993003.02384-2020 |
| PubMed: | View item in PubMed |
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