![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplemental Material)
9MB |
| Item Type: | Article |
|---|---|
| Title: | Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo |
| Creators Name: | Hirche, C. and Frenz, T. and Haas, S.F. and Döring, M. and Borst, K. and Tegtmeyer, P.K. and Brizic, I. and Jordan, S. and Keyser, K. and Chhatbar, C. and Pronk, E. and Lin, S. and Messerle, M. and Jonjic, S. and Falk, C.S. and Trumpp, A. and Essers, M.A.G. and Kalinke, U. |
| Abstract: | Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long-lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants. |
| Keywords: | Hematopoietic Stem Cells, Quiescence, Cell Cycle, Stem Cell Activation, Systemic Inflammation, Inflammatory Cytokines, Virus Infections, Stem Cell Function, Bone Marrow Transplantation, Transplant Complications, Animals, Mice |
| Source: | Cell Reports |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 19 |
| Number: | 11 |
| Page Range: | 2345-2356 |
| Date: | 13 June 2017 |
| Official Publication: | https://doi.org/10.1016/j.celrep.2017.05.063 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
