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Causes and consequences of hematopoietic stem cell heterogeneity

Item Type:Review
Title:Causes and consequences of hematopoietic stem cell heterogeneity
Creators Name:Haas, S. and Trumpp, A. and Milsom, M.D.
Abstract:Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs). Classically, stem and progenitor populations have been considered discrete homogeneous populations. However, recent technological advances have revealed significant HSC heterogeneity, with evidence for early HSC lineage segregation and the presence of lineage-biased HSCs and lineage-restricted progenitors within the HSC compartment. These and other findings challenge many aspects of the classical view of HSC biology. We review the most recent findings regarding the causes and consequences of HSC heterogeneity, discuss their far-reaching implications, and suggest that so-called continuum-based models may help consolidate apparently divergent experimental observations in this field.
Keywords:Hematopoiesis, Stem Cell Heterogeneity, Stem Cell Clonality, Hematopoietic Hierarchy, Single Cell Gene Expression, Lineage Tracing, Single Cell Transplantation, Leukemogenesis, Epigenetics, Differentiation, Animals
Source:Cell Stem Cell
Publisher:Cell Press
Page Range:627-638
Date:3 May 2018
Official Publication:https://doi.org/10.1016/j.stem.2018.04.003
PubMed:View item in PubMed

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