Helmholtz Gemeinschaft


Systems biology approach to study cancer metabolism

Item Type:Book Section
Title:Systems biology approach to study cancer metabolism
Creators Name:Kempa, S. and Royla, N.
Abstract:Transformation of cells into tumor cells is directly linked to a reprogramming of metabolism. Thus genomic or epigenomic alterations translate into adaptations of the biochemical phenotype of a cell. We are just at the beginning of understanding the mechanisms behind the metabolic reprogramming of metabolism as it includes all regulatory levels; (epi-) genomic, (post) transcriptional, (post) translational, and allosteric. In order to decode the regulatory mechanisms during metabolic reprogramming a systems view is needed that allows to follow the flow of information from the genome to metabolism.
Keywords:Gene Regulation, Metabolic Feedback, Metabolomics, Stable Isotope Resolved Metabolomics (pSIRM), Systems Biology
Source:Encyclopedia of Cancer
Title of Book:Encyclopedia of Cancer
Publisher:Elsevier / Academic Press
Page Range:426-428
Official Publication:https://doi.org/10.1016/B978-0-12-801238-3.65125-5

Repository Staff Only: item control page

Open Access
MDC Library