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SMART: recent updates, new developments and status in 2020

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Item Type:Article
Title:SMART: recent updates, new developments and status in 2020
Creators Name:Letunic, I. and Khedkar, S. and Bork, P.
Abstract:SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article. All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt, Ensembl and STRING, greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART's vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available.
Keywords:Protein Databases, Internet, Molecular Sequence Annotation, Phylogeny, Protein Binding, Tertiary Protein Structure, Proteins, Software
Source:Nucleic Acids Research
Publisher:Oxford University Press
Page Range:D458-D460
Date:8 January 2021
Official Publication:https://doi.org/10.1093/nar/gkaa937
PubMed:View item in PubMed

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